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Type-II Collagen - Scientific Review on Usage, Dosage, Side Effects _ Examine

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  16/12/2017Type-II Collagen - Scientific Review on Usage, Dosage, Side Effects | Examine.com Type-II Collagen Type II collagen (CII) is a peptide and component of joint cartilage. It's oral ingestion appears to reduce autoimmunityto the body's own CII, resulting in less inammation in instances of osteoarthritis and rheumatism and benets to joint health. This page features 70 unique references  to scientic papers. History (/history/type-ii-collagen/) Follow this Page for updates Things to Know Also Known As hydrolyzed collagen, solubilized collagen, CII, shark gelatin, gelatin, collagen Do Not Confuse With Colostrum (/supplements/colostrum/) (dierent protein with a similar name) Things to Note CII supplements are derived from animals and thus not vegan-friendly Is a Form Of   Joint HealthProtein supplement THINGS TO KNOWHOW TO TAKEHUMAN EFFECT MATRIXSCIENTIFIC RESEARCHCITATIONS  () SUPPLEMENTSNUTRITIONSTORE  16/12/2017Type-II Collagen - Scientific Review on Usage, Dosage, Side Effects | Examine.com How to Take Recommended dosage, active amounts, other details Collagen supplements are taken in one of two dierent forms, either in the form of hydrolyzed collagen  or in the form of an undenatured type II collagen ; both forms have dierent dosing strategies and while their benets may share some similarities can beconsidered two dierent supplements. Hydrolyzed collagen  is taken in doses of around 10g a day for skin health and some benets to joints, and can be taken with meals. Itshould not be taken in higher doses as a protein supplement (/supplements/protein-supplement/) (for muscle gain and fat loss) dueto having less ecacy than other protein sources and a lacklustre amino acid prole. Undenatured collagen  is taken at a lower dose of approximately 40mg once daily for the treatment of osteoarthritis and rheumatoidarthritis when there is an autoimmune component to it, and while it doesn't need to be taken at any particular time of the day it maybe ideal to take it on an empty stomach before breakfast. Human Eect Matrix The Human Eect Matrix  looks at human studies (it excludes animal and in vitro  studies) to tell you what eects type-iicollagen has on your body, and how strong these eects are. Robust research conducted with repeated double-blind clinical trialsMultiple studies where at least two are double-blind and placebo controlledSingle double-blind study or multiple cohort studiesUncontrolled or observational studies only Caution Notice Medical Disclaimer (/disclaimer) GRADELEVEL OF EVIDENCE  ()  16/12/2017Type-II Collagen - Scientific Review on Usage, Dosage, Side Effects | Examine.com Pain (/topics/pain/)- - See all 5 studies(/rubric/eects/view/839b39e8cef9fbc65648eed925d9bb30/359502a00fa29552278471ce3a9e4b72/all/)C-Reactive Protein(/topics/c-reactive-protein/)- - See study(/rubric/eects/view/839b39e8cef9fbc65648eed925d9bb30/e330349211447ab4b950446e202f1994/all/)Exercise-induced Joint Pain(/topics/exercise-induced-joint-pain/)- - See study(/rubric/eects/view/839b39e8cef9fbc65648eed925d9bb30/e7feac1c417180f2ca8f73a7ce2fe1af8655f480/all/)Immunoglobulin A(/topics/immunoglobulin-a/)- - See study(/rubric/eects/view/839b39e8cef9fbc65648eed925d9bb30/276e5d70198c835f332dd7a89e04655b37c3291a/allImmunoglobulin G(/topics/immunoglobulin-g/)- - See study(/rubric/eects/view/839b39e8cef9fbc65648eed925d9bb30/114361518a221eab8e2e4e57a4902d12cb279ec5/allSymptoms of Osteoarthritis(/topics/symptoms-of-osteoarthritis/)- - See 2 studies(/rubric/eects/view/839b39e8cef9fbc65648eed925d9bb30/846e9c6e95a32a8d804f103dde3f80/all/)Symptoms of RheumatoidArthritis(/topics/symptoms-of-rheumatoid-arthritis/)- - See all 3 studies(/rubric/eects/view/839b39e8cef9fbc65648eed925d9bb30/8ae640cee7e3edaf86b5bcc003d24557/all/) Studies Excluded from Consideration Note: The above HEM contains information on both hydrolyzed collagen supplements and undenatured collagensupplements despite signicant dose dierences between the two Scientic Research Table of Contents: LEVEL OFEVIDENCE ? OUTCOMEMAGNITUDE OF EFFECT ? CONSISTENCY OF RESEARCH RESULTS ? NOTES Used alongside calcitonin injections [1] Confounded with chondroitin (/supplements/chondroitin/) and hyaluronic acid [2] 1   Sources and Composition  Sources and Composition 1.1  ()  16/12/2017Type-II Collagen - Scientific Review on Usage, Dosage, Side Effects | Examine.com 1 Sources and Composition  Physicochemical Properties 1.2  Biological Relevance 1.3  Formulations and Variants 1.42   Molecular Targets  Tolerogenic Dendritic Cells 2.13   Pharmacology  Absorption 3.1  Distribution 3.2  Elimination 3.34   Neurology  Neurogenesis 4.15   Bone and Joint Health  Osteoblasts 5.1  Collagen and Joints 5.2  Osteoarthritis 5.3  Rheumatoid Arthritis 5.46   Inammation and Immunology  Interferons and Immunglobulins 6.1  Interleukins 6.2  T Cells 6.37   Interactions with Aesthetics  Skin 7.18   Safety and Toxicology  General 8.1  ()
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