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Psychiatric comorbidities in patients with brain tumors after radiotherapy – An intermediate report

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Introduction Primary or secondary CNS tumors are among the most difficult tomanage forms of cancer. Treatment of these tumors remains a challenge in oncology and the success rates for treatment of brain tumors are much lower than in extracerebral
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  S242  24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 EW368  The mediating role of metacogition inthe relation between intolerance of uncertainty and obsessive-compulsivedisorder S.Y. Sohn 1 , ∗ , I. Sohn 1 , S.Y. Lee 2 , S. Kim 1 1 YonseiUniversityCollegeofMedicine,DepartmentofPsychiatryandInstitute of Behavioral Science in Medicine, Seoul, Republic of Korea  2 Dankook University College of Medicine, Cheil General Hospital & Women’s healthcare center, Psychiatry, Seoul, Republic of Korea ∗ Corresponding author.Introduction  Obsessive-compulsive disorder (OCD) is a severeand incapacitating psychiatric disorder that is characterized byrecurrent intrusive thoughts (obsession). Maladaptive metacogni-tion have been found to be associated with anxiety and variouspsychopathology. Also, intolerance of uncertainty is considered tobe related with anxiety and ambivalence. These characteristics areconsidered to be key characteristics of OCD. Objectives  This study conceptualized metacognition as a medi-ator in the relation between intolerance of uncertainty andobsessive-compulsive symptom.  Aims  Thisstudywasaimedtofindprerequisitesfordevelopmentof OCD. Methods  The recruitment includes 150 OCD subjects and 50healthy controls. Subjects were investigated with the metacog-nition questionnaire (MCQ) and intolerance of uncertaintyquestionnaire(IOU)asself-reportmeasures.ParticipantswithOCDcompleted the Obsessive-Compulsive Inventory-Revised (OCI-R).The OCI-R taps six OCD symptom dimensions: checking, hoarding,neutralizing, obsessing, ordering and washing. Results  OCDsubjectsshowedsignificantlyhighermetacognitionscoreandsignificantlyhigherintoleranceofuncertaintyscorethancontrol group. In OCD group, the results indicated that metacog-nition partially mediated the relationship between intolerance of uncertainty and obsessing. Conclusions  Our findings suggest that metacognition mayexplainthe mechanismbywhichintolerance of uncertaintyexertsits effect on obsession. Disclosure of interest   The authors have not supplied their decla-ration of competing interest.http://dx.doi.org/10.1016/j.eurpsy.2016.01.486 Oncology and psychiatry  EW369 Psychiatric comorbidities in patients with brain tumors afterradiotherapy – An intermediatereport M. Bran 1 , ∗ , M. Ladea 2 , D. Stanculescu 3 , T. Purnichi 3 1 Coltea Clinical Hospital, Bucharest, Romania  2 University of Medicine and Pharmacy “Carol Davila”, Psychiatry,Bucharest, Romania  3 Clinical Hospital of Psychiatry “Prof. Dr. Al Obregia”, Psychiatry,Bucharest, Romania ∗ Corresponding author.Introduction  Primary or secondary CNS tumors are among themostdifficulttomanageformsofcancer.Treatmentofthesetumorsremainsachallengeinoncologyandthesuccessratesfortreatmentof brain tumors are much lower than in extracerebral localiza-tions. Because most chemotherapeutic agents do not cross theblood-brain barrier effectively and surgery is sometimes only pal-liative, radiotherapy remains the main method of treatment of these lesions. Both localized and generalized brain radiotherapyhave numerous psychiatric complications. Objectives  Theobjectiveofthestudywastoassessthepsychiatriccomorbiditiesinpatientswithbraintumorsreceivingradiotherapy.  Aims  Thisisanintermediatereportofalargerstudythatassessescomorbidities in patients with brain tumors after radiotherapy. Methods  Twenty-five patients with different localization braintumors were included in this observational study before receiv-ingradiotherapy.AllpatientswereassessedusingHospitalAnxietyandDepressionScale(HADS)foranxietyanddepressivesymptoms,Montreal Cognitive Assessment (MOCA) for cognitive impairmentandQualityofLifeEnjoymentandSatisfactionQuestionnaire–ShortForm (Q-LES-Q-SF) at inclusion and after 3months from finishingthe radiotherapy sessions. Results  Twenty-twopatientscompletedthestudy.Ninepatientsreceived antidepressant treatment (sertraline, tianeptine) duringthe study for depressive symptoms or anxiety. Patients receivingantidepressants showed better scores on HADS, MOCA and Q-LES-Q-SF scales. Conclusions  Antidepressant use in patients receiving radiothe-rapyforbraintumorscouldbeneuroprotectiveandcouldimprovequality of life. Disclosure of interest   The authors have not supplied their decla-ration of competing interest.http://dx.doi.org/10.1016/j.eurpsy.2016.01.487 EW370 Defence mechanisms and coping skillsin oncology patients C. Bredicean 1 , ∗ , C. Giurgi-Oncu 1 , I. Papava 1 , R. Romosan 1 ,A. Jurma 1 , M. Cristanovici 2 , M. Hurmuz 3 , A. Popescu 3 1 “Victor Babes” University of Medicine and Pharmacy, Neuroscience,Timisoara, Romania  2 South London and Maudsley NHS Foundation Trust, Mental HealthLearning Disabilities–Bethlem Royal Hospital Psychiatric, MentalHealth Learning Disabilities, London, United Kingdom  3 “Eduard Pamfil” Psychiatric Clinic Timisoara, Psychiatry, Timisoara,Romania ∗ Corresponding author.Introduction  Oncology-related illnesses have become quite fre-quent in our lives. Lately, medical progress in the field of oncologyhasledtoanincreaseinthesurvivalratesofpeoplediagnosedwithcancer. The minimisation of disturbances in the lives of these peo-pleisdonebyeachontheirown,byusingdefencemechanismsandcoping skills. Objectives  To identify the coping and defence mechanisms of subjects diagnosed with cancer compared with non-clinical sub- jects.  Aims  Toincreasequalityoflifeofsubjectsdiagnosedwithcancerthrough psychotherapy interventions. Method  Nineteen subjects diagnosed with cancer who werereceiving chemotherapy were recruited to the study. For compari-son,acontrolgroupofnon-clinicalparticipantswerealsorecruited.Participants were included into the study according to particularinclusion/exclusion criteria. The evaluation was conducted during2014 and consisted of the analysis of the following parameters:socio-demographic data, clinical data, defence mechanisms (DSQ-60) and coping mechanisms (COPE scale). Results  The group of subjects diagnosed with cancer demon-strated the presence of defence mechanisms of the followingtype: passive aggressiveness, projection and coping mechanismsthat were characterised by an emphasis on social support.The control group had defence mechanisms of the followingtypes: repression, denial and coping mechanisms that focused onemotions.
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