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Intravital imaging in zebrafish using quantum dots

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Background/aims: Fluorescent quantum dots (QDs) are powerful multipurpose interfaces of nanotechnology providing long-term and multicolor imaging of cellular and molecular interactions. The application of QDs in living organisms is just beginning to
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    포스터 전시  139 󰀹 Intra󰁶ital imaging in 󰁺ebrafish 󰁵sing q󰁵ant󰁵m dots 󰁄e󰁰󰁡󰁲󰁴 m e󰁮󰁴 of 󰁄e󰁲 m 󰁡󰁴o 󰁬 o gy 󰀬 C o 󰁬󰁬 e g e of 󰁍 ed󰁩󰁣󰁩󰁮e󰀬 K o󰁲e󰁡 󰁕 󰁮󰁩 󰁶 e󰁲s󰁩󰁴 y 󰀬 󰀱 L 󰁡 󰁢 o󰁲󰁡󰁴o󰁲 y  of N e 󰁵 󰁲ode 󰁶 e 󰁬 o󰁰 m e󰁮󰁴󰁡 󰁬   G e󰁮e󰁴󰁩󰁣s󰀬 G 󰁲󰁡d 󰁵 󰁡󰁴e 󰁓󰁣hoo 󰁬  of 󰁍 ed󰁩󰁣󰁩󰁮e󰀬 K o󰁲e󰁡 󰁕 󰁮󰁩 󰁶 e󰁲s󰁩󰁴 y 󰀬 󰀲 󰁄e󰁰󰁡󰁲󰁴 m e󰁮󰁴 of A󰁰󰁰 󰁬 󰁩ed C he m 󰁩s󰁴󰁲 y 󰀬 H 󰁡󰁮 y 󰁡󰁮 g   󰁕 󰁮󰁩 󰁶 e󰁲s󰁩󰁴 y Sa󰁮󰁧 W󰁯󰁯󰁫 S󰁯󰁮 Ja󰁥 H󰁷a󰁮 󰁋󰁩󰁭 S󰁵 H󰁹󰁵󰁮 󰁋󰁩󰁭   H󰁯 󰁋󰁩󰁭   A󰁨󰀭Y󰁯󰁵󰁮󰁧 C󰁨󰁵󰁮󰁧   Ja󰁥 B󰁵󰁭 C󰁨󰁯󰁯   I󰁬 H󰁷a󰁮 󰁋󰁩󰁭 C󰁨󰁩󰁬 H󰁷a󰁮 O󰁨 Ha󰁥󰀭C󰁨󰁵󰁬 󰁐a󰁲󰁫   F󰁬󰁵 o󰁲es󰁣e󰁮󰁴 󰁱󰁵 󰁡󰁮󰁴 󰁵m  do󰁴s 󰀨 󰁑 󰁄s) 󰁡󰁲e 󰁰o󰁷e󰁲f 󰁵󰁬   m󰁵󰁬 󰁴󰁩󰁰 󰁵 󰁲󰁰ose 󰁩󰁮󰁴e󰁲f󰁡󰁣es of 󰁮󰁡󰁮o󰁴e󰁣h󰁮o 󰁬 o gy  󰁰󰁲o 󰁶 󰁩d󰁩󰁮 g   󰁬 o󰁮 g󰀭 󰁴e󰁲 m  󰁡󰁮d m󰁵󰁬 󰁴󰁩󰁣o 󰁬 o󰁲 󰁩 m 󰁡 g 󰁩󰁮 g  of 󰁣e 󰁬󰁬󰁵󰁬 󰁡󰁲 󰁡󰁮d m o 󰁬 e󰁣 󰁵󰁬 󰁡󰁲 󰁩󰁮󰁴e󰁲󰁡󰁣󰁴󰁩o󰁮s󰀮 󰁔 he 󰁡󰁰󰁰 󰁬 󰁩󰁣󰁡󰁴󰁩o󰁮 fo󰁲 󰁑 󰁄s 󰁩󰁮 󰁬 󰁩 󰁶 󰁩󰁮 g  o󰁲 g 󰁡󰁮󰁩s m s h󰁡s 󰁪󰁵 s󰁴 󰁢 e g󰁵 󰁮 󰁴o 󰁢 e e x 󰁰 󰁬 o󰁲ed󰀬 󰁡󰁮d z e 󰁢 󰁲󰁡f󰁩sh e m󰁢 󰁲 y os 󰁣󰁡󰁮 󰁢 e s 󰁵 󰁩󰁴ed 󰁶 e󰁲󰁴e 󰁢 󰁲󰁡󰁴e m ode 󰁬  o󰁲 g 󰁡󰁮󰁩s m  fo󰁲 󰁩󰁮󰁴󰁲󰁡 󰁶 󰁩󰁴󰁡 󰁬  󰁩 m 󰁡 g 󰁩󰁮 g  󰁷󰁩󰁴h 󰁑 󰁄s󰀮 󰁔 o 󰁩󰁮 󰁶 es󰁴󰁩 g 󰁡󰁴e 󰁴he󰁩󰁲 󰁰o󰁴e󰁮󰁴󰁩󰁡 󰁬 s 󰁩󰁮 s󰁫󰁩󰁮 󰁲ese󰁡󰁲󰁣h󰀬 󰁷e 󰁵 sed 󰁑 󰁄s 󰁡s m 󰁩󰁣󰁲o󰁡󰁮 g 󰁩o g 󰁲󰁡󰁰h y  󰁣o󰁮󰁴󰁲󰁡s󰁴 󰁡 g e󰁮󰁴 󰁡󰁮d 󰁴󰁲󰁩ed 󰁴o 󰁶 󰁩s 󰁵 󰁡 󰁬 󰁩 z e 󰁣󰁡󰁲d󰁩o 󰁶 󰁡s󰁣 󰁵󰁬 󰁡󰁲 s y s󰁴e m  󰁩󰁮 z e 󰁢 󰁲󰁡f󰁩sh󰀮 W e 󰁡 󰁬 so 󰁴󰁲󰁩ed 󰁴o f󰁩󰁮d 󰁰󰁡󰁴h󰁷󰁡 y  󰁲e 󰁬 󰁡󰁴󰁩o󰁮sh󰁩󰁰 󰁢 e󰁴󰁷ee󰁮 󰁣󰁡󰁲d󰁩o 󰁶 󰁡s󰁣 󰁵󰁬 󰁡󰁲 s y s󰁴e m  󰁡󰁮d 󰁮e󰁲 󰁶 e 󰁮e󰁴󰁷o󰁲󰁫 󰁢y   󰁵 s󰁩󰁮 g   󰁑 󰁄s 󰁴o g e󰁴he󰁲 󰁷󰁩󰁴h 󰁴󰁲󰁡󰁮s g e󰁮󰁩󰁣 z e 󰁢 󰁲󰁡f󰁩sh 󰁬 󰁩󰁮e󰀮 󰁑󰁵 󰁡󰁮󰁴 󰁵m  󰁄o󰁴 󰁑 󰁄605󰀬 󰁷h󰁩󰁣h 󰁲e 󰁶 e󰁡 󰁬 s g 󰁲ee󰁮 󰁣o 󰁬 o󰁲 󰁵 󰁮de󰁲 󰁴he f 󰁬󰁵 o󰁲es󰁣e󰁮󰁴 m 󰁩󰁣󰁲os󰁣o󰁰e󰀬 󰁷󰁡s 󰁵 sed 󰁡s m 󰁩󰁣󰁲o󰁡󰁮 g 󰁩o g 󰁲󰁡󰁰h y  󰁣o󰁮󰁴󰁲󰁡s󰁴 󰁡 g e󰁮󰁴󰀮 󰁏󰁬 󰁩 g 2 󰀭 󰁄s󰁲ed 󰁴󰁲󰁡󰁮s g e󰁮󰁩󰁣 z e 󰁢 󰁲󰁡f󰁩sh 󰁬 󰁩󰁮e󰀬 󰁷h󰁩󰁣h e x 󰁰󰁲esses m o󰁴o󰁲 󰁮e 󰁵 󰁲o󰁮s 󰁩󰁮 󰁲ed 󰁣o 󰁬 o󰁲󰀬 󰁷󰁡s 󰁵 sed 󰁴o g e󰁴he󰁲 󰁷󰁩󰁴h 󰁑 󰁄s󰀮 Im 󰁡 g es of 󰁑 󰁄605 󰀭 󰁩󰁮 󰁪 e󰁣󰁴ed e m󰁢 󰁲 y os 󰁷e󰁲e 󰁲e󰁣o󰁲ded 󰁷󰁩󰁴h 󰁡 d󰁩 g 󰁩󰁴󰁡 󰁬  󰁣󰁡 m e󰁲󰁡󰀮 C o m󰁢 󰁩󰁮󰁩󰁮 g   g 󰁲ee󰁮 f 󰁬󰁵 o󰁲es󰁣e󰁮󰁣e of 󰁑 󰁄605 󰁡󰁮d 󰁲ed f 󰁬󰁵 o󰁲es󰁣e󰁮󰁣e of o 󰁬 󰁩 g 2 󰀭 󰁄s󰁲ed 󰁴󰁲󰁡󰁮s g e󰁮󰁩󰁣 z e 󰁢 󰁲󰁡f󰁩sh󰀬 󰁷e 󰁣o 󰁵󰁬 d o 󰁢 󰁴󰁡󰁩󰁮 de󰁴󰁡󰁩 󰁬 ed 󰁩 m 󰁡 g es m 󰁡󰁮󰁩fes󰁴󰁩󰁮 g  s󰁰󰁡󰁴󰁩󰁡 󰁬  󰁲e 󰁬 󰁡󰁴󰁩o󰁮sh󰁩󰁰 󰁢 e󰁴󰁷ee󰁮 󰁶 󰁡s󰁣 󰁵󰁬 󰁡󰁲 󰁡󰁮d 󰁮e󰁲 󰁶 o 󰁵 s s y s󰁴e m  of z e 󰁢 󰁲󰁡f󰁩sh 󰁑 󰁄s 󰁣o 󰁵󰁬 d 󰁢 e e󰁡s󰁩 󰁬y  e m 󰁰 󰁬 o y ed 󰁡s 󰁢 󰁲󰁩 g h󰁴 m 󰁩󰁣󰁲o󰁡󰁮 g 󰁩o g 󰁲󰁡󰁰h y  󰁡 g e󰁮󰁴 󰁩󰁮 󰁬 󰁩 󰁶 󰁩󰁮 g  e m󰁢 󰁲 y os󰀮 󰁏󰁵 󰁲 󰁩 m 󰁡 g e of 󰁶 󰁡s󰁣 󰁵󰁬 󰁡󰁲 󰁡󰁮d m o󰁴o󰁲 󰁮e󰁲 󰁶 o 󰁵 s s y s󰁴e m  󰁩󰁮 z e 󰁢 󰁲󰁡f󰁩sh sho󰁷ed 󰁴he󰁩󰁲 s󰁩 m 󰁩 󰁬 󰁡󰁲 󰁰󰁡󰁴󰁴e󰁲󰁮 of 󰁴󰁲󰁡 󰁪 e󰁣󰁴o󰁲 y  o 󰁶 e󰁲󰁡 󰁬󰁬 󰀮 H o󰁷e 󰁶 e󰁲󰀬 󰁴he󰁩󰁲 se gm e󰁮󰁴ed 󰁲e󰁰e󰁴󰁩󰁴󰁩 󰁶 e 󰁮e󰁴󰁷o󰁲󰁫s 󰁡 󰁬 o󰁮 g  󰁴he do󰁲so 󰁶 e󰁮󰁴󰁲󰁡 󰁬  󰁡 x 󰁩s 󰁷e󰁲e 󰁮o󰁴 󰁣o m 󰁰 󰁬 e󰁴e 󰁬y  o 󰁶 e󰁲 󰁬 󰁡󰁰󰁰ed󰀮 󰀱 󰁅ffe󰁣t of 󰁅G󰁃G on 󰁣ell 󰁣󰁹󰁣le󰀬 apoptosis and lipid prod󰁵󰁣tion in S󰁅󰁂󰀭󰀱 sebo󰁣󰁹tes 󰀱 󰁁󰁣󰁮󰁥 󰁒󰁥󰁳󰁥󰁡󰁲󰁣󰁨 󰁌󰁡󰁢󰁯󰁲󰁡󰁴󰁯󰁲󰁹󰀬 󰁓󰁥󰁯󰁵󰁬 󰁎󰁡󰁴󰁩󰁯󰁮󰁡󰁬 󰁕󰁮󰁩󰁶󰁥󰁲󰁳󰁩󰁴󰁹 󰁈󰁯󰁳󰁰󰁩󰁴󰁡󰁬󰀬 󰀲 󰁄󰁥󰁰󰁡󰁲󰁴󰁭󰁥󰁮󰁴 󰁯󰁦 󰁄󰁥󰁲󰁭󰁡󰁴󰁯󰁬󰁯󰁧󰁹󰀬 󰁓󰁥󰁯󰁵󰁬 󰁎󰁡󰁴󰁩󰁯󰁮󰁡󰁬 󰁕󰁮󰁩󰁶󰁥󰁲󰁳󰁩󰁴󰁹 󰁃󰁯󰁬󰁬󰁥󰁧󰁥 󰁯󰁦 󰁍󰁥󰁤󰁩󰁣󰁩󰁮󰁥󰀬 󰀳 󰁄󰁥󰁰󰁡󰁲󰁴󰁭󰁥󰁮󰁴 󰁯󰁦 󰁄󰁥󰁲󰁭󰁡󰁴󰁯󰁬󰁯󰁧󰁹󰀬 󰁐󰁥󰁮󰁮󰁳󰁹󰁬󰁶󰁡󰁮󰁩󰁡 󰁓󰁴󰁡󰁴󰁥 󰁕󰁮󰁩󰁶󰁥󰁲󰁳󰁩󰁴󰁹 󰁃󰁯󰁬󰁬󰁥󰁧󰁥 󰁯󰁦 󰁍󰁥󰁤󰁩󰁣󰁩󰁮󰁥󰀬 󰁈󰁥󰁲󰁳󰁨󰁥󰁹󰀬 󰁕󰁓󰁁 김진숙   윤미영   민성욱  󰀬 D󰁩a󰁮󰁥 M󰀮 T󰁨󰁩b󰁯󰁵󰁴󰁯󰁴 󰀳  서대헌  󰀬 󰀠 󰁍󰁡󰁮󰁹 󰁦󰁡󰁶󰁯󰁲󰁡󰁢󰁬󰁥 󰁥󰁦󰁦󰁥󰁣󰁴󰁳 󰁯󰁦 󰁧󰁲󰁥󰁥󰁮 󰁴󰁥󰁡󰀬 󰁳󰁵󰁣󰁨 󰁡󰁳 󰁡󰁮󰁴󰁩󰀭󰁩󰁮󰁦󰁬󰁡󰁭󰁭󰁡󰁴󰁯󰁲󰁹󰀬 󰁡󰁮󰁴󰁩󰁢󰁡󰁣󰁴󰁥󰁲󰁩󰁡󰁬󰀬 󰁡󰁮󰁤 󰁡󰁮󰁴󰁩󰁭󰁵󰁴󰁡󰁧󰁥󰁮󰁩󰁣 󰁡󰁣󰁴󰁩 󰁶 󰁩󰁴󰁩es󰀬 h󰁡 󰁶 e 󰁢 ee󰁮 󰁲e󰁰o󰁲󰁴ed󰀮 I 󰁮 o 󰁵 󰁲 󰁰󰁲e 󰁶 󰁩o 󰁵 s s󰁴 󰁵 d y 󰀬 󰀨 󰀭 ) 󰀭 e󰁰󰁩 g 󰁡 󰁬󰁬 o󰁣󰁡󰁴e󰁣h󰁩󰁮 󰀭 3 󰀭g 󰁡 󰁬󰁬 󰁡󰁴e 󰀨 EGCG ) 󰁩 m 󰁰󰁲o 󰁶 ed 󰁡󰁣󰁮e 󰁬 es󰁩o󰁮 󰁢y  󰁩󰁮h󰁩 󰁢 󰁩󰁴󰁩o󰁮 of 󰁐 󰀮 󰁡󰁣󰁮es 󰁡󰁮d 󰁩󰁴 󰁡 󰁬 so 󰁩󰁮d 󰁵 󰁣ed 󰁴he e x 󰁰󰁲ess󰁩o󰁮 of 󰁴󰁲󰁡󰁮s g󰁬󰁵 󰁴󰁡 m 󰁩󰁮󰁡ses󰀮 󰁔 h󰁩s s󰁴 󰁵 d y  󰁷󰁡s 󰁰e󰁲fo󰁲 m ed 󰁴o e x 󰁡 m 󰁩󰁮e 󰁴he effe󰁣󰁴 of EGCG  o󰁮 󰁩 mm o󰁲󰁴󰁡 󰁬 󰁩 z ed se 󰁢 o󰁣 y 󰁴e 󰁣e 󰁬󰁬   󰁬 󰁩󰁮e 󰀨󰁓 E󰁂󰀭 1) 󰁡󰁮d 󰁴o de󰁴e󰁲 m 󰁩󰁮e 󰁷he󰁴he󰁲 EGCG  󰁣󰁡󰁮 󰁩󰁮d 󰁵 󰁣e 󰁡󰁰o󰁰󰁴os󰁩s of 󰁓 E󰁂󰀭 1󰀮 󰁔 o 󰁴es󰁴 󰁴he effe󰁣󰁴 of EGCG  o󰁮 󰁓 E󰁂󰀭 1 󰁶 󰁩󰁡 󰁢 󰁩 󰁬 󰁩󰁴 y 󰀬 󰁣e 󰁬󰁬 s 󰁷e󰁲e 󰁩󰁮󰁣 󰁵󰁢 󰁡󰁴ed fo󰁲 2󰀴󰀬 󰀴󰀸󰀬 o󰁲 󰀷2 ho 󰁵 󰁲s 󰁷󰁩󰁴h 0󰀬 5󰀬 10󰀬 20󰀬 󰁡󰁮d 󰀴0 μ󰁍   EGCG 󰀮 󰁔 o de󰁴e󰁲 m 󰁩󰁮e 󰁴he effe󰁣󰁴 of EGCG  o󰁮 󰁬 󰁩󰁰󰁩d s y 󰁮󰁴hes󰁩s󰀬 󰁓 E󰁂󰀭 1 se 󰁢 o󰁣 y 󰁴es 󰁷e󰁲e 󰁩󰁮󰁣 󰁵󰁢 󰁡󰁴ed fo󰁲 󰀷2 ho 󰁵 󰁲s 󰁷󰁩󰁴h 0 󰁴o 󰀴0 μ󰁍   EGCG 󰀮 󰁔LC  󰁷󰁡s 󰁰e󰁲fo󰁲 m ed 󰁡f󰁴e󰁲 󰁴o󰁴󰁡 󰁬   󰁬 󰁩󰁰󰁩d e x 󰁴󰁲󰁡󰁣󰁴󰁩o󰁮 f󰁲o m  󰁴he se 󰁢 o󰁣 y 󰁴es 󰁡󰁮d 󰁩󰁴 󰁷󰁡s 󰁡󰁮󰁡 󰁬yz ed fo󰁲 󰁩󰁮d󰁩 󰁶 󰁩d 󰁵 󰁡 󰁬   󰁬 󰁩󰁰󰁩d 󰁣o󰁮󰁴e󰁮󰁴s󰀮 󰁒 es 󰁵󰁬 󰁴s sho󰁷ed 󰁴h󰁡󰁴 EGCG  󰁣󰁡 󰁵 sed dose 󰀭 de󰁰e󰁮de󰁮󰁴 󰁡󰁮d 󰁴󰁩 m e 󰀭 de󰁰e󰁮de󰁮󰁴 de󰁣󰁲e󰁡se 󰁩󰁮 󰁶 󰁩󰁡 󰁢󰁬 e 󰁓 E󰁂󰀭 1 se 󰁢 o󰁣 y 󰁴es󰀮 A 󰁰o󰁲󰁴󰁩o󰁮 of 󰁴h󰁩s de󰁣󰁲e󰁡se 󰁣o 󰁵󰁬 d 󰁢 e 󰁡󰁴󰁴󰁲󰁩 󰁢󰁵 󰁴ed 󰁴o 󰁣e 󰁬󰁬  󰁣 y 󰁣 󰁬 e 󰁡 󰁬 󰁴e󰁲󰁡󰁴󰁩o󰁮 󰁢y  de󰁣󰁲e󰁡sed 󰁣 y 󰁣 󰁬 󰁩󰁮 󰁄1󰀮 EGCG  󰁩󰁮d 󰁵 󰁣ed 󰁡󰁰o󰁰󰁴os󰁩s 󰁩󰁮 󰁓 E󰁂󰀭 1 se 󰁢 o󰁣 y 󰁴es 󰁷󰁩󰁴h 󰁴he f󰁩󰁮d󰁩󰁮 g s of 󰁩󰁮󰁣󰁲e󰁡sed 󰁣 󰁬 e󰁡 󰁶 ed 󰁣󰁡s󰁰󰁡se 3 󰁡󰁮d 󰁂 󰁡 x/󰁂 󰁣 󰁬󰀭 2 󰁰󰁲o󰁴e󰁩󰁮 󰁲󰁡󰁴󰁩o󰀮 EGCG  󰁩󰁮h󰁩 󰁢 󰁩󰁴ed 󰁬 󰁩󰁰󰁩d 󰁡󰁣󰁣 󰁵m󰁵󰁬 󰁡󰁴󰁩o󰁮 󰁩󰁮 󰁓 E󰁂󰀭 1 se 󰁢 o󰁣 y 󰁴es dose 󰀭 de󰁰e󰁮de󰁮󰁴 󰁬y 󰀮 󰁔 hese 󰁲es 󰁵󰁬 󰁴s de m o󰁮s󰁴󰁲󰁡󰁴e 󰁴h󰁡󰁴 EGCG  󰁣󰁡󰁮 󰁡󰁣󰁴 d󰁩󰁲e󰁣󰁴 󰁬y  󰁴o 󰁩󰁮h󰁩 󰁢 󰁩󰁴 󰁣e 󰁬󰁬  󰁰󰁲o 󰁬 󰁩fe󰁲󰁡󰁴󰁩o󰁮 󰁡󰁮d 󰁴o 󰁩󰁮d 󰁵 󰁣e 󰁣e 󰁬󰁬  󰁣 y 󰁣 󰁬 e 󰁡󰁲󰁲es󰁴 󰁡󰁮d 󰁡󰁰o󰁰󰁴os󰁩s󰀮 󰁔 hese m e󰁣h󰁡󰁮󰁩s m s m 󰁡 y  󰁣o󰁮󰁴󰁲󰁩 󰁢󰁵 󰁴e 󰁴o 󰁴he 󰁲e󰁡so󰁮s 󰁴h󰁡󰁴 EGCG  󰁣󰁡󰁮 󰁢 e 󰁡󰁮 effe󰁣󰁴󰁩 󰁶 e 󰁡 g e󰁮󰁴 fo󰁲 󰁴he 󰁴󰁲e󰁡󰁴 m e󰁮󰁴 of 󰁡󰁣󰁮e󰀮 󰀱󰀱 󰁅󰁸󰁰󰁲󰁥󰁳󰁳󰁩󰁯󰁮 󰁯󰁦 󰁨󰁥󰁡󰁴 󰁳󰁨󰁯󰁣󰁫 󰁰󰁲󰁯󰁴󰁥󰁩󰁮 󰀷󰀰 󰁩󰁮 󰁨󰁵󰁭󰁡󰁮 󰁳󰁫󰁩󰁮 󰁣󰁥󰁬󰁬󰁳 󰁡󰁳 󰁡 󰁰󰁨󰁯󰁴󰁯󰁰󰁲󰁯󰁴󰁥󰁣󰁴󰁩󰁶󰁥 󰁦󰁵󰁮󰁣󰁴󰁩󰁯󰁮 󰁡󰁦󰁴󰁥󰁲 󰁕󰁖 󰁥󰁸󰁰󰁯󰁳󰁵󰁲󰁥 󰁄e󰁰󰁡󰁲󰁴 m e󰁮󰁴 of 󰁄e󰁲 m 󰁡󰁴o 󰁬 o gy 󰀬 C o 󰁬󰁬 e g e of 󰁍 ed󰁩󰁣󰁩󰁮e󰀬 󰁓󰁯󰁯󰁮󰁣󰁨󰁵󰁮󰁨󰁹󰁡󰁮󰁧 󰁕󰁮󰁩󰁶󰁥󰁲󰁳󰁩󰁴󰁹 B󰁹󰁯󰁵󰁮󰁧 H󰁷a R󰁯󰁨 Da󰁥 H󰁹󰁵󰁮 󰁋󰁩󰁭 M󰁯󰁯󰁮 󰁋󰁹󰁵󰁮 C󰁨󰁯 Y󰁯󰁵󰁮󰁧 L󰁩󰁰 󰁐a󰁲󰁫 󰁋󰁹󰁵 Ua󰁮󰁧 W󰁨a󰁮󰁧 󰁂 󰁡󰁣󰁫 g 󰁲o 󰁵 󰁮d 󰀺   H󰁵m 󰁡󰁮 s󰁫󰁩󰁮 󰁩s e x 󰁰osed 󰁴o 󰁶 󰁡󰁲󰁩o 󰁵 s e󰁮 󰁶 󰁩󰁲o󰁮 󰀭m e󰁮󰁴󰁡 󰁬  s󰁴󰁲esses s 󰁵 󰁣h 󰁡s he󰁡󰁴󰀬 󰁣o 󰁬 d󰀬 󰁵󰁬 󰁴󰁲󰁡 󰁶 󰁩o 󰁬 e󰁴 󰀨 󰁕󰁖 )󰀮 H e󰁡󰁴 sho󰁣󰁫 󰁰󰁲o󰁴e󰁩󰁮s 󰁡󰁲e 󰁩󰁮d 󰁵 󰁣ed 󰁢y  e 󰁬 e 󰁶 󰁡󰁴󰁩o󰁮 of 󰁴e m 󰁰e󰁲󰁡󰁴 󰁵 󰁲e 󰁡s 󰁰h y s󰁩o 󰁬 o g 󰁩󰁣 󰁲es󰁰o󰁮se 󰁴o m ed󰁩󰁡󰁴e 󰁲e󰁰󰁡󰁩󰁲 m e󰁣h󰁡󰁮󰁩s m  󰁡󰁮d 󰁫ee󰁰 󰁡󰁷󰁡 y  f󰁲o m  󰁣e 󰁬󰁬󰁵󰁬 󰁡󰁲 d󰁡 m 󰁡 g e󰀮 󰁏󰁢󰁪 e󰁣󰁴󰁩 󰁶 es 󰀺   󰁔 he 󰁰 󰁵 󰁲󰁰ose of 󰁴h󰁩s s󰁴 󰁵 d y  󰁩s 󰁴o 󰁩󰁮 󰁶 es󰁴󰁩 g 󰁡󰁴e 󰁴he 󰁩󰁮d 󰁵 󰁣󰁴󰁩o󰁮 of he󰁡󰁴 sho󰁣󰁫 󰁰󰁲o󰁴e󰁩󰁮 󰁩󰁮 h 󰁵m 󰁡󰁮 s󰁫󰁩󰁮 󰁣e 󰁬󰁬 s 󰁡f󰁴e󰁲 󰁕󰁖  e x 󰁰os 󰁵 󰁲e󰀮 󰁍 e󰁴hods 󰀺   W e 󰁰e󰁲 󰀭 fo󰁲 m ed 󰁩 mm󰁵 󰁮o 󰁢󰁬 o󰁴󰁴󰁩󰁮 g   󰁵 s󰁩󰁮 g  󰁡 s󰁰e󰁣󰁩f󰁩󰁣 m o󰁮o󰁣 󰁬 o󰁮󰁡 󰁬  󰁡󰁮󰁴󰁩 󰀭󰁢 od y  󰁴o H 󰁓 󰁐 󰀷0 f󰁡 m 󰁩 󰁬y  󰀨 H 󰁓 󰁐 󰀷0)󰀬 󰁷h󰁩󰁣h 󰁩s o󰁮e of 󰁴he 󰁢 es󰁴 󰀭 󰁣o󰁮se󰁲 󰁶 ed s󰁴󰁲ess 󰁰󰁲o󰁴e󰁩󰁮s 󰁩󰁮 󰁴he h 󰁵m 󰁡󰁮 s y s󰁴e m  󰁷󰁩󰁴h 󰁣 󰁵󰁬 󰁴 󰁵 󰁲ed 󰁮o󰁲 m 󰁡 󰁬  h 󰁵m 󰁡󰁮 󰁫e󰁲󰁡󰁴󰁩󰁮o󰁣 y 󰁴es󰀬 A󰀴31 󰁣e 󰁬󰁬 s󰀬 h 󰁵m 󰁡󰁮 m e 󰁬 󰁡󰁮o󰁣 y 󰁴es󰀬 󰁓 K 30 󰁣e 󰁬󰁬 s 󰁡󰁮d h 󰁵m 󰁡󰁮 de󰁲 m 󰁡 󰁬  f󰁩 󰁢 󰁲o 󰁢󰁬 󰁡s󰁴s󰀮  󰀲󰀰󰀰󰀸년 제󰀶󰀰차 대한피부과학회 추계학술대회   140 󰁒 es 󰁵󰁬 󰁴 󰀺   󰁏󰁵 󰁲 󰁲es 󰁵󰁬 󰁴s 󰁩󰁮d󰁩󰁣󰁡󰁴ed 󰁴h󰁡󰁴 h󰁩 g h e x 󰁰󰁲ess󰁩o󰁮 of H 󰁓 󰁐 󰀷0 󰁩󰁮 󰁴he 󰁵 󰁮s󰁴󰁲esseds󰁴󰁡󰁴e 󰁷󰁡s 󰁮o󰁴ed 󰁩󰁮 e󰁰󰁩de󰁲 m 󰁡 󰁬  󰁣e 󰁬󰁬 s󰀨󰁩󰁮󰁣 󰁬󰁵 d 󰀭 󰁩󰁮 g  󰁮o󰁲 m 󰁡 󰁬  h 󰁵m 󰁡󰁮 󰁫e󰁲󰁡󰁴󰁩󰁮o󰁣 y 󰁴es󰀬 A󰀴31 󰁣e 󰁬󰁬 s󰀬 h 󰁵m 󰁡󰁮 m e 󰁬 󰁡 󰀭 󰁮o󰁣 y 󰁴es󰀬 󰁓 K 30 󰁣e 󰁬󰁬 s)󰀬 󰁢󰁵 󰁴 e󰁰󰁩de󰁲 m 󰁡 󰁬  󰁣e 󰁬󰁬 s sho󰁷ed 󰁮o m o󰁲e 󰁵 󰁰󰁲e g󰁵󰁬 󰁡󰁴󰁩o󰁮 of H 󰁓 󰁐 󰀷0 󰁡f󰁴e󰁲 󰁕󰁖  󰁩󰁲󰁲󰁡d󰁩󰁡󰁴󰁩o󰁮󰀮 󰁏 󰁮 󰁴he o󰁴he󰁲 h󰁡󰁮d󰀬 h 󰁵m 󰁡󰁮 de󰁲 m 󰁡 󰁬  f󰁩 󰁢 󰁲o 󰁢󰁬 󰁡s󰁴s 󰀨 H 󰁄 F ) e x 󰁰󰁲essed 󰁶 e󰁲 y  s m 󰁡 󰁬󰁬  󰁡 m o 󰁵 󰁮󰁴 of H 󰁓 󰁐 󰀷0 󰁩󰁮 󰁴he 󰁢 󰁡se 󰁬 󰁩󰁮e󰀬 󰁢󰁵 󰁴 s󰁩 g 󰁮󰁩f󰁩󰁣󰁡󰁮󰁴 󰁬y  h󰁩 g h 󰁡 m o 󰁵 󰁮󰁴s of H 󰁓 󰁐 󰀷0 󰁡f󰁴e󰁲 󰁕󰁖  e x 󰁰os 󰁵 󰁲e󰀮 C o󰁮󰁣 󰁬󰁵 s󰁩o󰁮 󰀺   󰁔 hese f󰁩󰁮d󰁩󰁮 g   m 󰁡 y  s 󰁵gg es󰁴 󰁴h󰁡󰁴 󰁣o󰁮s󰁴󰁩󰁴 󰁵 󰁴󰁩 󰁶 e e x 󰁰󰁲ess󰁩o󰁮 of H 󰁓 󰁐 󰀷0 󰁩󰁮 e󰁰󰁩de󰁲 m 󰁡 󰁬  󰁣e 󰁬󰁬 s m 󰁡 y   󰁢 e 󰁡󰁮 󰁩 m 󰁰o󰁲󰁴󰁡󰁮󰁴 m e󰁣h󰁡󰁮󰁩s m  fo󰁲 󰁴he 󰁰󰁲o󰁴e󰁣󰁴󰁩o󰁮 of h 󰁵m 󰁡󰁮 e󰁰󰁩de󰁲 m 󰁩s f󰁲o m  e󰁮 󰁶 󰁩󰁲o󰁮 m e󰁮󰁴󰁡 󰁬  s󰁴󰁲esses s 󰁵 󰁣h 󰁡s s 󰁵 󰁮 󰁬 󰁩 g h󰁴 e x 󰁰os 󰁵 󰁲e󰀮  󰀱󰀲 󰁏󰁶ere󰁸pression of Id󰀳 enhan󰁣es X󰀭ra󰁹󰀭ind󰁵󰁣ed apoptosis thro󰁵gh p󰀵󰀳󰀭dependent me󰁣hanism 󰁄e󰁰󰁡󰁲󰁴 m e󰁮󰁴 of 󰁄e󰁲 m 󰁡󰁴o 󰁬 o gy 󰀬 󰀱 󰁄e󰁰󰁡󰁲󰁴 m e󰁮󰁴 of 󰁒 󰁡d󰁩󰁡󰁴󰁩o󰁮 󰁏 󰁮󰁣o 󰁬 o gy 󰀬 󰁓󰁣hoo 󰁬  of 󰁍 ed󰁩󰁣󰁩󰁮e󰀬 C h 󰁵 󰁮 g 󰁮󰁡 m   N 󰁡󰁴󰁩o󰁮󰁡 󰁬   󰁕 󰁮󰁩 󰁶 e󰁲s󰁩󰁴 y E󰁵󰁮 󰁋󰁹󰁯󰁵󰁮󰁧 J󰁥󰁯󰁮 Y󰁯󰁵󰁮󰁧󰀭S󰁯󰁯󰁫 L󰁥󰁥 󰁋󰁩󰀭H󰁷a󰁮 󰁋󰁩󰁭   M󰁯󰁯󰁮󰀭J󰁵󰁮󰁥 C󰁨󰁯   Y󰁯󰁵󰁮󰁧 L󰁥󰁥 C󰁨a󰁮󰁧 D󰁥󰁯󰁫 󰁋󰁩󰁭 Y󰁯󰁵󰁮󰁧󰀭J󰁯󰁯󰁮 S󰁥󰁯 Ja󰁮󰁧󰀭󰁋󰁹󰁵 󰁐a󰁲󰁫 J󰁥󰁵󰁮󰁧󰀭H󰁯󰁯󰁮 L󰁥󰁥 I 󰁮h󰁩 󰁢 󰁩󰁴o󰁲 of d󰁩ffe󰁲e󰁮󰁴󰁩󰁡󰁴󰁩o󰁮 / 󰁄 N A 󰁢 󰁩󰁮d󰁩󰁮 g  󰀨 I d) 󰁰󰁲o󰁴e󰁩󰁮s 󰁣o m 󰁰󰁲󰁩se 󰁡 󰁣 󰁬 󰁡ss of he 󰁬 󰁩 x󰀭󰁬 oo󰁰 󰀭 he 󰁬 󰁩 x  󰁴󰁲󰁡󰁮s󰁣󰁲󰁩󰁰󰁴󰁩o󰁮 f󰁡󰁣󰁴o󰁲s 󰁴h󰁡󰁴 h󰁡 󰁶 e 󰁶 󰁡󰁲󰁩o 󰁵 s 󰁲o 󰁬 es 󰁩󰁮 󰁰󰁲o 󰁬 󰁩fe󰁲󰁡󰁴󰁩o󰁮󰀬 d󰁩ffe󰁲e󰁮󰁴󰁩󰁡󰁴󰁩o󰁮󰀬 󰁡󰁰o󰁰󰁴os󰁩s󰀬 󰁡󰁮d 󰁣󰁡󰁲󰁣󰁩󰁮o g e󰁮es󰁩s󰀮 W e 󰁰󰁲e 󰁶 󰁩o 󰁵 s 󰁬y  sho󰁷ed 󰁴h󰁡󰁴 I d3󰀬 o󰁮e of I d 󰁰󰁲o󰁴e󰁩󰁮 s 󰁵 󰁰e󰁲f󰁡 m 󰁩 󰁬y 󰀬 󰁩s 󰁩󰁮d 󰁵 󰁣ed 󰁢y   󰁘󰀭 󰁲󰁡 y  󰁩󰁲󰁲󰁡d󰁩󰁡󰁴󰁩o󰁮 󰁩󰁮 󰁡󰁮󰁩 m 󰁡 󰁬   m ode 󰁬  fo󰁲 󰁲󰁡d󰁩ode󰁲 m 󰁡󰁴󰁩󰁴󰁩s󰀮 I 󰁮 󰁴h󰁩s s󰁴 󰁵 d y 󰀬 󰁷e 󰁩󰁮 󰁶 es󰁴󰁩 g 󰁡󰁴e 󰁴he f 󰁵 󰁮󰁣󰁴󰁩o󰁮󰁡 󰁬  󰁲o 󰁬 e of I d3 󰁩󰁮 󰁘󰀭 󰁲󰁡 y  󰁩󰁲󰁲󰁡d󰁩󰁡󰁴ed 󰁡󰁰o󰁰󰁴os󰁩s of s󰁫󰁩󰁮 󰁫e󰁲󰁡󰁴󰁩󰁮o󰁣 y 󰁴es󰀮 󰁔 o 󰁴h󰁩s e󰁮d󰀬 󰁷e e x 󰁡 m 󰁩󰁮ed 󰁴he e x 󰁰󰁲ess󰁩o󰁮 of I d3 󰁵 s󰁩󰁮 g   󰁒󰁔󰀭󰁐C󰁒  󰁡󰁮d 󰁩 mm󰁵 󰁮oh󰁩s󰁴o󰁣he m 󰁩s󰁴󰁲 y 󰀬 󰁡󰁮d 󰁩󰁮 󰁶 es󰁴󰁩 g 󰁡󰁴ed 󰁴he effe󰁣󰁴 of I d3 o󰁮 󰁣e 󰁬󰁬  󰁣 y 󰁣 󰁬 e 󰁡󰁮d 󰁡󰁰o󰁰󰁴os󰁩s 󰁵 s󰁩󰁮 g  󰁡 󰁲e󰁣o m󰁢 󰁩󰁮󰁡󰁮󰁴 󰁡de󰁮o 󰁶 󰁩󰁲 󰁵 s󰀮 󰁘󰀭 󰁲󰁡 y  󰁩󰁲󰁲󰁡d󰁩󰁡󰁴󰁩o󰁮 m 󰁡󰁲󰁫ed 󰁬y  󰁩󰁮d 󰁵 󰁣ed I d3 e x 󰁰󰁲ess󰁩o󰁮 󰁩󰁮 󰁴he h y 󰁰e󰁲󰁰 󰁬 󰁡s󰁴󰁩󰁣 e󰁰󰁩de󰁲 m 󰁩s of m o 󰁵 se󰀮 I 󰁮󰁴e󰁲es󰁴󰁩󰁮 g󰁬y 󰀬 o 󰁶 e󰁲e x 󰁰󰁲ess󰁩o󰁮 of I d3 󰁩󰁮 H 󰁡 C 󰁡 󰁔   󰁢y  󰁡de󰁮o 󰁶 󰁩󰁲󰁡 󰁬  󰁴󰁲󰁡󰁮sd 󰁵 󰁣󰁴󰁩o󰁮 󰁬 ed 󰁴o 󰁴he 󰁩󰁮h󰁩 󰁢 󰁩󰁴󰁩o󰁮 of 󰁣e 󰁬󰁬  󰁰󰁲o 󰁬 󰁩fe󰁲󰁡󰁴󰁩o󰁮 󰁩󰁮 󰁴he 󰁡 󰁢 se󰁮󰁣e 󰁡󰁮d / o󰁲 󰁰󰁲ese󰁮󰁣e of 󰁘󰀭 󰁲󰁡 y  󰁩󰁲󰁲󰁡d󰁩󰁡󰁴󰁩o󰁮󰀬 󰁡s 󰁣o m 󰁰󰁡󰁲ed 󰁷󰁩󰁴h Ad /L 󰁡󰁣 󰁚  󰁣o󰁮󰁴󰁲o 󰁬   g 󰁲o 󰁵 󰁰󰀮 C o󰁮󰁣o m 󰁩󰁴󰁡󰁮󰁴 󰁬y 󰀬 o 󰁶 e󰁲e x 󰁰󰁲ess󰁩o󰁮 of I d3 s󰁩 g 󰁮󰁩f󰁩󰁣󰁡󰁮󰁴 󰁬y  󰁩󰁮󰁣󰁲e󰁡sed 󰁴he 󰁘󰀭 󰁲󰁡 y󰀭 󰁩󰁮d 󰁵 󰁣ed 󰁡󰁰o󰁰󰁴os󰁩s 󰁩󰁮 H 󰁡 C 󰁡 󰁔  󰁫e󰁲󰁡󰁴󰁩󰁮o󰁣 y 󰁴es󰀮 I 󰁮 󰁡dd󰁩󰁴󰁩o󰁮󰀬 I d3 o 󰁶 e󰁲e x 󰁰󰁲ess󰁩o󰁮 󰁲es 󰁵󰁬 󰁴ed 󰁩󰁮 󰁡󰁣󰁣 󰁵m󰁵󰁬 󰁡󰁴󰁩o󰁮 of 󰁰53 󰁡󰁮d 󰁵 󰁰󰁲e g󰁵󰁬 󰁡󰁴󰁩o󰁮 of 󰁰21󰀬 s 󰁵gg es󰁴󰁩󰁮 g  󰁴he I d3 󰁡ffe󰁣󰁴s 󰁣e 󰁬󰁬󰁵󰁬 󰁡󰁲 󰁡󰁰o󰁰󰁴os󰁩s 󰁶 󰁩󰁡 󰁴he 󰁰53 󰀭 de󰁰e󰁮de󰁮󰁴 󰁰󰁡󰁴h󰁷󰁡 y 󰀮 󰁔 hese 󰁲es 󰁵󰁬 󰁴s 󰁩 m 󰁰 󰁬 󰁩󰁣󰁡󰁴e 󰁴he 󰁰o󰁴e󰁮󰁴󰁩󰁡 󰁬  󰁩󰁮 󰁶 o 󰁬󰁶 e m e󰁮󰁴 of I d3 󰁩󰁮 󰁘󰀭 󰁲󰁡 y󰀭 󰁩󰁮d 󰁵 󰁣ed 󰁡󰁰o󰁰󰁴os󰁩s of s󰁫󰁩󰁮 󰁫e󰁲󰁡󰁴󰁩󰁮o󰁣 y 󰁴es󰀮  󰀱󰀳 󰁒elationship bet󰁷een iris 󰁣olor and skin 󰁣olor 󰁄e󰁰󰁡󰁲󰁴 m e󰁮󰁴 of 󰁄e󰁲 m 󰁡󰁴o 󰁬 o gy 󰀬 K o󰁲e󰁡 󰁕 󰁮󰁩 󰁶 e󰁲s󰁩󰁴 y J󰁩 W󰁯󰁯󰁮󰁧 󰁋󰁩󰁭 E󰁵󰁩 J󰁯󰁮󰁧 Ba󰁥 Ja󰁥 E󰁵󰁮 C󰁨󰁯󰁩 S󰁯󰁯 H󰁯󰁮󰁧 S󰁥󰁯 H󰁹󰁯 H󰁹󰁵󰁮 A󰁨󰁮 Y󰁯󰁵󰁮󰁧 C󰁨󰁵󰁬 󰁋󰁹󰁥 I 󰁲󰁩s 󰁣o 󰁬 o󰁲 h󰁡s 󰁢 ee󰁮 󰁣o󰁮s󰁩de󰁲ed 󰁡󰁮 󰁡ffe󰁣󰁴󰁩󰁮 g  f󰁡󰁣󰁴o󰁲 󰁴o s󰁫󰁩󰁮 󰁣o 󰁬 o󰁲󰀮 󰁂󰁵 󰁴 󰁵 󰁮󰁴󰁩 󰁬  󰁲e󰁣e󰁮󰁴 󰁬y 󰀬 󰁣 󰁬 󰁡ss󰁩f󰁩󰁣󰁡󰁴󰁩o󰁮 s y s󰁴e m  of 󰁩󰁲󰁩s 󰁣o 󰁬 o󰁲 h󰁡s 󰁢 ee󰁮 s 󰁵󰁢󰁪 e󰁣󰁴󰁩 󰁶 e 󰁡󰁮d 󰁮o󰁴 s 󰁵 󰁩󰁴󰁡 󰁢󰁬 e es󰁰e󰁣󰁩󰁡 󰁬󰁬y  fo󰁲 As󰁩󰁡󰁮 󰁰o󰁰 󰁵󰁬 󰁡󰁴󰁩o󰁮 fo󰁲 󰁴he󰁩󰁲 󰁲e 󰁬 󰁡󰁴󰁩 󰁶 e ho m o g e󰁮e󰁩󰁴 y  of 󰁩󰁲󰁩s 󰁣o 󰁬 o󰁲󰀮 󰁓o󰀬 󰁱󰁵 󰁡󰁮󰁴󰁩󰁴󰁡󰁴󰁩 󰁶 e s󰁴 󰁵 d y  󰁡 󰁢 o 󰁵 󰁴 󰁲e 󰁬 󰁡󰁴󰁩o󰁮 of 󰁩󰁲󰁩s 󰁣o 󰁬 o󰁲 󰁡󰁮d s󰁫󰁩󰁮 󰁣o 󰁬 o󰁲 󰁩s 󰁲󰁡󰁲e󰀮 󰁔 he 󰁰 󰁵 󰁲󰁰ose of 󰁴h󰁩s s󰁴 󰁵 d y  󰁷󰁡s 󰁴o de 󰁶 󰁩se 󰁡󰁮 o 󰁢󰀭󰁪 e󰁣󰁴󰁩 󰁶 e m e󰁴hod 󰁴o m e󰁡s 󰁵 󰁲e h 󰁵m 󰁡󰁮 󰁩󰁲󰁩s 󰁣o 󰁬 o󰁲 󰁱󰁵 󰁡󰁮󰁴󰁩󰁴󰁡󰁴󰁩 󰁶 e 󰁬y  󰁡󰁮d 󰁴o 󰁡ssess 󰁩󰁴s de󰁲 m 󰁡󰁴o 󰁬 o g 󰁩󰁣󰁡 󰁬  s󰁩 g 󰁮󰁩f󰁩󰁣󰁡󰁮󰁣e󰀮 W e de 󰁶 󰁩sed 󰁰ho󰁴o g 󰁲󰁡󰁰h󰁩󰁣 s y s󰁴e m  󰁴o 󰁡󰁣 󰁱󰁵 󰁩󰁲e 󰁡de 󰁱󰁵 󰁡󰁴e 󰁩󰁲󰁩s 󰁩 m 󰁡 g es fo󰁲 󰁣o 󰁬 o󰁲󰁩 m e󰁴󰁲󰁩󰁣 󰁩󰁮 󰁶 es󰁴󰁩 g 󰁡󰁴󰁩o󰁮s󰀮 󰁔 o f󰁩󰁮d 󰁴he de󰁲 m 󰁡󰁴o 󰁬 o g 󰁩󰁣󰁡 󰁬  s󰁩 g󰀭 󰁮󰁩f󰁩󰁣󰁡󰁮󰁣e󰀬 󰁷e 󰁴oo󰁫 󰁰󰁩󰁣󰁴 󰁵 󰁲es of 󰀴󰀷 K o󰁲e󰁡󰁮 󰁰󰁡󰁴󰁩e󰁮󰁴s󰀮 󰁔 he y  󰁷e󰁲e e 󰁶 󰁡 󰁬󰁵 󰁡󰁴ed 󰁷󰁩󰁴h 󰁲e g 󰁡󰁲d 󰁴o 󰁩󰁲󰁩s 󰁣o 󰁬 o󰁲󰀬 󰁣o 󰁬 o󰁲 of s 󰁵 󰁮 󰀭 e x󰀭 󰁰osed 󰁡󰁮d s 󰁵 󰁮 󰀭 󰁰󰁲o󰁴e󰁣󰁴ed s󰁫󰁩󰁮 󰁡󰁮d de󰁲 m 󰁡󰁴o 󰁬 o g 󰁩󰁣 d󰁩󰁡 g 󰁮os󰁩s󰀮 I 󰁴 󰁷󰁡s 󰁰oss󰁩 󰁢󰁬 e 󰁴o 󰁱󰁵 󰁡󰁮󰁴󰁩f y  󰁴he 󰁩󰁲󰁩s 󰁣o 󰁬 o󰁲󰀬 s󰁫󰁩󰁮 󰁣o 󰁬 o󰁲 󰁡󰁮d 󰁩󰁴s d󰁩ffe󰁲e󰁮󰁣e 󰁩󰁮 󰁣o 󰁬 o󰁲󰁩 m e󰁴󰁲󰁩󰁣 󰁷󰁡 y s 󰁵 s󰁩󰁮 g  󰁴he m e󰁴hods 󰁩󰁮 󰁴h󰁩s s󰁴 󰁵 d y 󰀮 L 󰁩 g h󰁴󰁮ess 󰀨 L󰀪 ) of s 󰁵 󰁮 󰀭 e x 󰁰osed s󰁫󰁩󰁮 󰁩s de󰁣󰁲e󰁡sed 󰁷󰁩󰁴h 󰁡 g e󰀮 L󰀪  of 󰁩󰁲󰁩s h󰁡s 󰁡 󰁰os󰁩󰁴󰁩 󰁶 e 󰁣o󰁲󰁲e 󰁬 󰁡󰁴󰁩o󰁮 󰁷󰁩󰁴h L󰀪  of s 󰁵 󰁮 󰀭 e x 󰁰osed s󰁫󰁩󰁮󰀮 L󰀪  of 󰁩󰁲󰁩s 󰁷󰁡s 󰁰os󰁩󰁴󰁩 󰁶 e 󰁬y  󰁣o󰁲󰁲e 󰁬 󰁡󰁴ed 󰁷󰁩󰁴h 󰁡 󰀪  󰁡󰁮d 󰁢󰀪  of 󰁩󰁲󰁩s 󰁲es󰁰e󰁣󰁴󰁩 󰁶 e 󰁬y 󰀮 A󰁮d 󰁴h󰁩s 󰁲e 󰁬 󰁡󰁴󰁩o󰁮s 󰁷e󰁲e 󰁶 e󰁲 y  s󰁩 m 󰁩 󰁬 󰁡󰁲 󰁷󰁩󰁴h 󰁴hose 󰁢 e󰁴󰁷ee󰁮 L󰀪  of 󰁩󰁲󰁩s 󰁡󰁮d e󰁡󰁣h of 󰁡 󰀪  󰁡󰁮d 󰁢󰀪  of s 󰁵 󰁮 󰀭 󰁰󰁲o󰁴e󰁣󰁴ed s󰁫󰁩󰁮󰀮 As L󰀪  of 󰁩󰁲󰁩s 󰁣o 󰁬 o󰁲 h󰁡s 󰁴he s󰁩 m󰀭 󰁩 󰁬 󰁡󰁲 󰁲e 󰁬 󰁡󰁴󰁩o󰁮s 󰁷󰁩󰁴h 󰁡 󰀪  󰁡󰁮d 󰁢󰀪  󰁩󰁮 󰁢 o󰁴h 󰁩󰁲󰁩s 󰁡󰁮d s 󰁵 󰁮 󰀭 󰁰󰁲o󰁴e󰁣󰁴ed s󰁫󰁩󰁮󰀬 󰁴he 󰁩󰁲󰁩s 󰁣o 󰁬 o󰁲 󰁷o 󰁵󰁬 d 󰁢 e 󰁡 󰁣 󰁬󰁵 e 󰁴o 󰁬 oo󰁫 fo󰁲 󰁡󰁮d def󰁩󰁮e 󰁣o󰁮s󰁴󰁩󰁴 󰁵 󰁴󰁩o󰁮󰁡 󰁬  s󰁫󰁩󰁮 󰁣o 󰁬 o󰁲󰀮  󰀱󰀴 Zebrafish에서의 elasti󰁣 tiss󰁵e 이 화 여자대학교 의학전문대학원 피부과학교실 오지은 최유원 명기범 최혜영 󰁚 e 󰁢 󰁲󰁡f󰁩sh 󰀨󰁄󰁡󰁮󰁩o 󰁲e󰁲󰁩o)는 빠르 게 발생하여 3일 이내에 거 의 모든 중요한 장기들이 형 성되며󰀬 발생 2󰀴시간 이내에는 알 의 막 이 투 명하여 발생의 초기과정을 현 미 경으로 볼 수 있고󰀬 유전학적 조 작 을 통해 발생에 관여하는 유전자의 식 별이 가 능 하다는 점 등으로 척추 동물의 발생을 연구하
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